pathway

Immune Response

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Immune Response: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2670Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

Immune Response is a biological pathway involved in neurodegeneration research. Key relationships include: activates, regulates, therapeutic target. Associated with ALS, Aging, Als. Connected to 1636 entities in the SciDEX knowledge graph.

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🔀 Pathway Info

Name	Immune Response
Key Genes/Proteins	TNF, STING, CGAS, OVERVIEW, TBK1, GENES
Related Diseases	Inflammation, Als, Cancer, Tumor, Alzheimer

Wiki Pages (20)

Knowledge base pages for this entity

cbs-psp-daily-action-plan

therapeutic · 30834 words

→

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

therapeutic · 15794 words

→

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Corticobasal Syndrome (CBS)

disease · 11374 words

→

Parkinson's Disease

disease · 8807 words

→

Pathway Diagram

graph TD
    Immune_Response["Immune Response"] -->|"interacts"| Oxidative_Stress["Oxidative Stress"]
    Immune_Response["Immune Response"] -->|"interacts"| Innate_Immunity["Innate Immunity"]
    Immune_Response["Immune Response"] -->|"interacts"| Epigenetic["Epigenetic"]
    Immune_Response["Immune Response"] -->|"interacts"| Glycolysis["Glycolysis"]
    Immune_Response["Immune Response"] -->|"interacts"| Oxidative_Phosphorylation["Oxidative Phosphorylation"]
    Immune_Response["Immune Response"] -->|"interacts"| Nf__b["Nf-Kappab"]
    HSPA1A["HSPA1A"] -->|"activates"| Immune_Response["Immune Response"]
    HSP70["HSP70"] -->|"contributes to"| Immune_Response["Immune Response"]
    MAX["MAX"] -.->|"inhibits"| Immune_Response["Immune Response"]
    CGAS["CGAS"] -->|"contributes to"| Immune_Response["Immune Response"]
    style Immune_Response fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (276)

Target	Relation	Type	Str
Aav-Delivered Crispr Therapy	inhibits	drug	0.90
Neurodegenerative Diseases	contributes_to	disease	0.85
Coronary Artery Disease	associated_with	disease	0.85
Neurodegenerative Diseases	involved_in	disease	0.85
ALS Subclusters	biomarker_for	biomarker	0.80
ALS	involved_in	disease	0.80
Oxidative Stress	interacts_with	pathway	0.55
Innate Immunity	interacts_with	pathway	0.55
Epigenetic	interacts_with	pathway	0.55
Glycolysis	interacts_with	pathway	0.55
Oxidative Phosphorylation	interacts_with	pathway	0.55
Nf-Κb	interacts_with	pathway	0.55
Angiogenesis	interacts_with	pathway	0.55
Adaptive Immunity	interacts_with	pathway	0.55
Mtor	interacts_with	pathway	0.55
Ferroptosis	interacts_with	pathway	0.55
Lipid Metabolism	interacts_with	pathway	0.55
Mitochondrial Function	interacts_with	pathway	0.55
Autophagy	interacts_with	pathway	0.55
Circadian Rhythm	interacts_with	pathway	0.55
Proteasome	interacts_with	pathway	0.55
Apoptosis	interacts_with	pathway	0.55
Lysosomal Degradation	interacts_with	pathway	0.55
Pyroptosis	interacts_with	pathway	0.55
Phagocytosis	interacts_with	pathway	0.55
Wnt	interacts_with	pathway	0.55
Complement	interacts_with	pathway	0.55
Mapk	interacts_with	pathway	0.55
Blood-Brain Barrier	interacts_with	pathway	0.55
Nf-Kb	interacts_with	pathway	0.55
Endothelial	contributes_to	cell_type	0.50
Stem Cell	therapeutic_target	cell_type	0.50
Microglia	therapeutic_target	cell_type	0.50
Stem Cell	activates	cell_type	0.50
Macrophage	regulates	cell_type	0.50
T Cell	activates	cell_type	0.50
Endothelial	activates	cell_type	0.50
T Cell	regulates	cell_type	0.50
T Cell	interacts_with	cell_type	0.50
B Cell	therapeutic_target	cell_type	0.50
Monocyte	activates	cell_type	0.50
T Cell	inhibits	cell_type	0.50
Monocyte	associated_with	cell_type	0.50
Fibroblast	associated_with	cell_type	0.50
Hepatocyte	regulates	cell_type	0.50
Microglia	expressed_in	cell_type	0.50
Neuron	expressed_in	cell_type	0.50
Dopaminergic	expressed_in	cell_type	0.50
Neuron	causes	cell_type	0.50
Neutrophil	activates	cell_type	0.50

Incoming (2394)

Source	Relation	Type	Str
TNF	activates	gene	1.00
STING	activates	gene	1.00
CGAS	activates	gene	1.00
OVERVIEW	regulates	gene	1.00
TBK1	activates	gene	1.00
Inflammation	activates	disease	1.00
Als	activates	disease	1.00
Cancer	inhibits	disease	1.00
Tumor	inhibits	disease	1.00
GENES	activates	gene	1.00
DNA	activates	gene	1.00
Cancer	therapeutic_target	disease	1.00
Alzheimer	therapeutic_target	disease	1.00
Tumor	regulates	disease	1.00
Tumor	activates	disease	1.00
Cancer	activates	disease	1.00
Cancer	regulates	disease	1.00
Als	regulates	disease	1.00
Inflammation	regulates	disease	1.00
DNA	associated_with	gene	1.00
Cancer	associated_with	disease	1.00
Als	associated_with	disease	1.00
Aging	associated_with	disease	1.00
GENES	therapeutic_target	gene	1.00
Inflammation	therapeutic_target	disease	1.00
Parkinson	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
Obesity	activates	disease	1.00
Aging	activates	disease	1.00
Neurodegeneration	regulates	disease	1.00
Aging	regulates	disease	1.00
Autoimmune	activates	disease	1.00
AKT	regulates	gene	1.00
Autoimmune	regulates	disease	1.00
GENES	regulates	gene	1.00
Alzheimer	regulates	disease	1.00
Als	inhibits	disease	1.00
Neurodegeneration	activates	disease	1.00
Alzheimer	activates	disease	1.00
Parkinson	activates	disease	1.00
Inflammation	associated_with	disease	1.00
Neuroinflammation	activates	disease	1.00
PI3K	activates	gene	1.00
AKT	activates	gene	1.00
NLRP3	activates	gene	1.00
Diabetes	therapeutic_target	disease	1.00
PI3K	regulates	gene	1.00
MTOR	regulates	gene	1.00
MIRNAS	regulates	gene	1.00
Stroke	activates	disease	1.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

How does APOE4's beneficial immune function reconcile with its established role

neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.588

How can CRISPR systems achieve persistent therapeutic effects while avoiding chr

gene therapy | 2026-04-11 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Immune Response

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Corticobasal Syndrome (CBS)

Parkinson's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

nhp-validation-animal-model

Neurons — Cell Type Hierarchy

Frontotemporal Dementia (FTD) Mechanistic Pathway

neuroinflammation

NRF2 Oxidative Stress Pathway

Alzheimer's Disease

Neuroimmune Response in 4R-Tauopathies: Cross-Disease Comparison

Growth Factor Therapies

Mitochondrial Dysfunction in Parkinson's Disease

Oligodendrocytes

TREM2 Microglial Signaling Pathway in Neurodegeneration

Vitamin D Signaling Pathway in Neurodegeneration